Genetic Alterations in Metastatic Urothelial Carcinoma

Finding actionable genetic alterations

Precision medicine is changing cancer care

The identification of actionable genetic alterations is becoming an essential strategy in the management of advanced cancers. A recent analysis found that nearly half of tumors harbor an actionable target.1*

Targeted agents based on genetic alterations have proven effective in treating subsets of various malignancies, including breast cancer, non-small cell lung cancer, and melanoma.2-4

FGFR is an actionable alteration

Specific genetic alterations can guide therapy in urothelial carcinoma

There are actionable genomic targets for certain patients who have progressed during or after first-line platinum-based chemotherapy treatment of metastatic urothelial carcinoma.5 Discover how the first FDA-approved treatment for mUC with susceptible FGFR3 or FGFR2 genetic alterations works.

*Single-arm, open-label study that evaluated the molecular profile of tumors from 843 patients with advanced cancers using high-throughput genomics. The most frequent tumor types included cancers of the digestive system (n=197), lung (n=170), urological system (n=158), breast (n=135), and head and neck (n=111).1

FDA = U.S. Food and Drug Administration; FGFR = fibroblast growth factor receptor.

References

1. Massard C, Michiels S, Ferté C, et al. High-throughput genomics and clinical outcome in hard-to-treat advanced cancers: results of the MOSCATO 01 trial. Cancer Discov. 2017;7(6):586-595. 2. Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med. 2006;355:2733-2743. 3. Peters S, Camidge DR, Shaw AT, et al. Alectinib versus crizotinib in untreated ALK-positive non–small-cell lung cancer. N Engl J Med. 2017;377:829-838. 4. Chapman PB, Robert C, Larkin J, et al. Vemurafenib in patients with BRAFV600 mutation-positive metastatic melanoma: final overall survival results of the randomized BRIM-3 study. Ann Oncol. 2017;28:2581-2587. 5. BALVERSA™ [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.